Design and Synthesis of Lactams Derived from Mucochloric and Mucobromic Acids as Pseudomonas aeruginosa Quorum Sensing Inhibitors

Bacterial infections, particularly hospital-acquired infections caused BODY TREATMENT by Pseudomonas aeruginosa, have become a global threat with a high mortality rate.Gram-negative bacteria including P.aeruginosa employ N-acyl homoserine lactones (AHLs) as chemical signals to regulate the expression of pathogenic phenotypes through a mechanism cal

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Surgical resection of glioma involving eloquent brain areas: Tumor boundary, functional boundary, and plasticity consideration

Glioma is the most refractory intracranial tumor, and its diffuse infiltrative growth characteristics make total resection impossible in a biological sense, especially when Napkins tumors invade eloquent brain areas.Thus, identifying the equilibrium between tumor resection and functional preservation remains a challenge in glioma surgery.The accura

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